Monday, January 26, 2009

Latisse: Are you ready for bigger lashes?

Bigger, thicker lashes. Sure, everyone looks better with them, but how far are we willing to go. It's been a while since the FDA approved bimatoprost for cosmeceutical use, a prescription drug originally used for glaucoma treatment. The simple gist is that glaucoma patients using this drug developed thicker, longer lashes. This little finding ended up being a jackpot for Allergan, the company behind the drug.


This is actually one example of a pharmaceutical company truly getting the ultimate success in a product, namely being able to repackage a drug for a secondary market, especially when the market is even larger than its orginal target audience. Sure Allergan may have had decent sales (over $100 million) with Lumigan (the glaucoma version of the drug), but we all know the real money is had in cosmeceuticals. Being able to repackage the drug for cosmeceutical use (under the name Latisse) is going to make Allergan more money, many times over, than they could have as a limited to glaucoma drug. In fact, sales are predicted to be over half a BILLION dollars, and product popularity will only continue to grow. Oh yeah, guess what other blockbuster product Allergan is behind? Botox! And they think that Latisse will rival sales of Botox!

But it's our job to take a closer look here at Truth in Skincare, right? So let's get into it now. The active ingredient in both these products is bimatoprost, which is similar to prostaglandins, basically fatty acid derived active compounds, which in this case, help decrease the pressure inside the eye. This is an essential activity to help relieve the pressure in Glaucoma and reduce damage to the optic nerve. Overall, it's a seemingly safe drug and cleared by the body extremely quickly. And there's no doubt to its benefits for glaucoma patients, but as a cosmetic agent, well, that's a different story.

First lets start with the side effects:

Occurring in up to half of all patients:
1. Increased blood flow (redness) in the eyes
2. Itchiness
3. Eyelash growth
4. Itchy eyes

In roughly 10% of patients:
1. Infections (colds and upper respiratory infections)

In roughly 5 to 10% of patients:
1. Headaches
2. Abnormal liver functions
3. Hirsuitism (excessive hairyness throughout entire body)

These side effects occur in roughly 3-10% of patients:
1. Dry eyes
2. Visual disturbances
3. Burning
4. Foreign body sensation
5. Eye pain
6. Cataracts
7. Eyelid redness
8. Eyelash darkening

Occurring in 1 to 3% of patients:
1. Eye discharge
2. Excessive tearing
3. Photophobia (sensitivity to light)
4. Allergic conjunctivitis (another form of "eye redness")
5. Strained eyes
6. Pigmentation of the iris
7. Eye swelling (edema)

Had enough yet?
So we're going to be using this active drug to lengthen out lashes! To be honest, I don't know how the FDA got around to approving this drug for cosmetic use. The concentration of the active ingredient is the same in both products, however, the application process is not the same. Lumigan (the glaucoma drug) is in the form of eye drops. However, Latisse, the cosmetic form is in drop form too, however, it is dropped onto an applicator. The applicator is then used to apply to the eyelash area, not directly into the eye (although it will find it's way into the eye anyway!).

On top of all this, it will require daily use and maximum results won't be found for 16 weeks. That means a dedication of 4 months! I don't know readers, what do you think? I think that there are probably more useful ways to devote your time than to this experimental beauty regime. The most unfortunate aspect is the people who most justifiably would need this are chemotherapy patients who have lost their eyelashes, but this is just one of the groups of people that the FDA suggests more research should be conducted. So, the people that may need this product the most are the ones that more research needs to be done in order to prove the product's safety and effectiveness.

Is it me, or does this seems like an excessive cosmetic regime that we can do without? For safety's sake (come on, do you want to go through any of the above side effects?) I'd recommend staying away from Latisse. Period. At least wait a few years to see what this products full effects will be. Now that this product is approved for cosmeceutical use, the number of patients using it is exploding as well, and we will soon find out what the full list of side effects are anyway.

I say . . . just be smart and don't be a guinea pig, stick to your favorite mascara for the time being!



Tuesday, January 6, 2009

Happy 2009!

A belated Happy New Year to the readers of this blog! I'm so excited to start this new year with fresh blogs and continued emails from all of you! Thanks so much for the kind words! Let me take a moment to wish you the best for this coming year and beyond.

While I talk much of skincare on this blog, certainly there are times I'd like to write about more important things such as what's happening in this world (and that's quite a lot huh?). So for this new year, of course I'll be writing more skincare blogs, but I'll also be throwing in some more personal rants and raves and writing about things I believe should be talked about.

I think in the bigger scope of things we can all agree that skincare takes a much needed backseat to other issues in our lives! As Americans, and with our current troubled economic times, there are certainly larger thoughts looming for us all. Expanding the scope of the blog I think will hopefully give it a more personal and interesting new depth (let's hope!). So, kinda like a plate of skincare with a side of current affairs!

Again, I wish you all the best in this new year and hope that whatever we are going through, good or bad, we can always be grateful for what we do have and plan to become better people to ourselves and to others as each day goes by.

Love, dr d